pharmacokinetics, dosage regimen and in vitro plasma protein binding of intramuscular levofloxacin in buffalo calves

نویسندگان

d. ram

v. k. dumka

s. k. sharma

h. s. sandhu

چکیده

the pharmacokinetics of levofloxacin following its single intramuscular administration (3 mg/kg) was investigated in six male buffalo calves. peak plasma level of 2.95 ± 0.13μg/ml was observed at 1 h and the drug level above mic90  in plasma was detected up to 12 h of administration. the bioavailability was 68.1 ± 5.4% and levofloxacin was bound to the plasma proteins to the extent of 19.1 ± 1.5%. high values of auc (8.81 ± 0.37μg.h/ml) and vdarea (1.06 ± 0.04 l/kg) reflected a vast area of body covered by drug concentration and appropriate penetration of levofloxacin into various body fluids and tissues. the elimination half-life and mean residence time were 3.27 ± 0.31 h and 5.4 ± 0.59 h, respectively. the total body clearance was 343.2 ± 14.1 ml/kg/h. an appropriate intramuscular dosage regimen for levofloxacin in buffalo calves would be 1.7 mg/kg repeated at 12-h intervals.

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Pharmacokinetics, dosage regimen and in vitro plasma protein binding of intramuscular levofloxacin in buffalo calves

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عنوان ژورنال:
iranian journal of veterinary research

ناشر: shiraz university

ISSN 1728-1997

دوره 9

شماره 2 2008

میزبانی شده توسط پلتفرم ابری doprax.com

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